abstract：:The cortisol rise after awakening (CAR) is a frequently applied measure of pituitary-adrenal activity. This measure seems to reflect the acrophase of the diurnal cycle and can easily be assessed in saliva samples, collected by the proband or patient under real life conditions. Since different state and trait factors a...

journal_title：Psychoneuroendocrinology

authors： Hellhammer J,Fries E,Schweisthal OW,Schlotz W,Stone AA,Hagemann D

更新日期：2007-01-01 00:00:00

abstract：:The normal diurnal cortisol cycle has a peak in the morning, decreasing rapidly over the day, with low levels during the night, then rising rapidly again to the morning peak. A pattern of flatter daytime slopes has been associated with more rapid cancer progression in both animals and humans. We studied the relationsh...

journal_title：Psychoneuroendocrinology

authors： Spiegel D,Giese-Davis J,Taylor CB,Kraemer H

更新日期：2006-11-01 00:00:00

abstract：:It is suggested that the symptoms of anorexia nervosa are physiological responses to starvation. There is no evidence of a neural or non-neural dysfunction that predisposes women for anorexia nervosa and the endocrine and psychological consequences of starvation are reversed once patients have re-learnt how to eat and...

journal_title：Psychoneuroendocrinology

authors： Södersten P,Bergh C,Zandian M

更新日期：2006-11-01 00:00:00

abstract：:Acute tryptophan depletion (ATD) is a technique that has been used to evaluate the effects on humans of acutely reducing serotonin neurotransmission. We have developed a model using a single breath of 35% CO(2) that activates the hormonal axis and produces autonomic and behavioural arousal, thus modelling a stress res...

journal_title：Psychoneuroendocrinology

authors： Hood SD,Hince DA,Robinson H,Cirillo M,Christmas D,Kaye JM

更新日期：2006-10-01 00:00:00

abstract：:A heightened cortisol awakening response (CAR) is associated with adiposity in middle-aged men, but the causal significance of this effect is not known. We hypothesised that if disturbance in cortisol secretion is involved in the development of overweight and obesity, then it might be present in normal weight adults a...

journal_title：Psychoneuroendocrinology

authors： Steptoe A,Wright CE,O'Donnell K,Brydon L,Wardle J

更新日期：2006-10-01 00:00:00

abstract：:Previous studies have shown that 17beta-estradiol (E2) induces antidepressant-like actions per se and potentiates those produced by fluoxetine (FLX) in the forced swimming test (FST). The aim of the present work was to explore the participation of serotonin 1A receptors (5-HT1A) and estrogen receptors (ERs) in the ant...

journal_title：Psychoneuroendocrinology

authors： Estrada-Camarena E,López-Rubalcava C,Fernández-Guasti A

更新日期：2006-09-01 00:00:00

abstract：:Estrogen secretion in young women follows a cyclic pattern characterized by a pronounced surge in estrogen around ovulation. The way in which this estrogen peak affects cognitive functioning is unclear. Short-term estrogen treatment for a few days mimicking normal pre-menopausal estrogen dynamics substantially enhance...

journal_title：Psychoneuroendocrinology

authors： Krug R,Born J,Rasch B

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-adrenal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD). METHODS:We examined neuroendocrine function in female survivors of intimate partner violence (IPV) with lifetime ...

journal_title：Psychoneuroendocrinology

authors： Inslicht SS,Marmar CR,Neylan TC,Metzler TJ,Hart SL,Otte C,McCaslin SE,Larkin GL,Hyman KB,Baum A

更新日期：2006-08-01 00:00:00

abstract：:There is accumulating evidence that a deficiency in brain-derived neurotrophic factor (BDNF) plays a critical role in the pathophysiology of depression. This is in line with the postulate that low BDNF levels in serum are associated with depression. However, the regulation of maternal BDNF serum levels in the perinata...

journal_title：Psychoneuroendocrinology

authors： Lommatzsch M,Hornych K,Zingler C,Schuff-Werner P,Höppner J,Virchow JC

更新日期：2006-04-01 00:00:00

abstract：:Burnout is presumed to be the result of chronic stress, and chronic stress is known to affect the HPA-axis. To date, studies on HPA-axis functioning in burnout have showed inconsistent results. In the present study, a large sample (n=74) of clinically diagnosed burnout individuals, mostly on sick-leave, were included ...

journal_title：Psychoneuroendocrinology

authors： Mommersteeg PM,Heijnen CJ,Verbraak MJ,van Doornen LJ

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Autism is a severe neurodevelopmental disorder characterized by impairment in communication, social interaction, repetitive behaviors and difficulty adapting to novel experiences. The Hypothalamic-Pituitary-Adrenocortical (HPA) system responds consistently to perceived novel or unfamiliar situations and can ...

journal_title：Psychoneuroendocrinology

authors： Corbett BA,Mendoza S,Abdullah M,Wegelin JA,Levine S

更新日期：2006-01-01 00:00:00

abstract：:Common physical symptoms such as abdominal pain, headache, back pain and dizziness play a major role for the health care system. Existing models for the development and maintenance of these symptoms emphasize a vicious circle with cognitive-perceptual, behavioral, and psychobiological components. In this manuscript, w...

journal_title：Psychoneuroendocrinology

authors： Rief W,Barsky AJ

更新日期：2005-11-01 00:00:00

abstract：:Behavioral data suggest that fear stimuli automatically activate fear and capture attention. This effect is likely to be mediated by a subcortical brain network centered on the amygdala. Consistent with this view, brain imaging studies show that masked facial stimuli activate the amygdala as do masked pictures of thre...

journal_title：Psychoneuroendocrinology

authors： Ohman A

更新日期：2005-11-01 00:00:00

abstract：:Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will pre...

journal_title：Psychoneuroendocrinology

authors： Fries E,Hesse J,Hellhammer J,Hellhammer DH

更新日期：2005-11-01 00:00:00

abstract：:Cognitive decline in old age is not universal or inevitable. Associations have been observed with neuroendocrine function, but the relevance of other physiological processes is unclear. We predicted that impairment of memory in an ageing population would be related to the dysregulation of neuroendocrine and cardiovasc...

journal_title：Psychoneuroendocrinology

authors： Wright CE,Kunz-Ebrecht SR,Iliffe S,Foese O,Steptoe A

更新日期：2005-10-01 00:00:00

abstract：:The purpose of this meta-analysis is to examine the association between depression and cortisol responses to psychological stressors. A total of seven studies comparing plasma or cortisol responses to psychological stressors in clinically depressed (MDD) and non-depressed (ND) individuals (N = 196: 98 MDD, 98 ND; 83 m...

journal_title：Psychoneuroendocrinology

authors： Burke HM,Davis MC,Otte C,Mohr DC

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Neurosteroids have been proposed to play an important role in the interaction between alcohol and GABA(A) receptors and for the symptomatology of premenstrual dysphoric disorder (PMDD). The primary aim of this study was to investigate possible alcohol-induced changes in allopregnanolone serum concentrations ...

journal_title：Psychoneuroendocrinology

authors： Nyberg S,Andersson A,Zingmark E,Wahlström G,Bäckström T,Sundström-Poromaa I

更新日期：2005-10-01 00:00:00

abstract：:In this study, basal saliva cortisol was determined in women at 32 weeks of pregnancy and again at 9 months post-partum. During pregnancy, the cortisol levels of the 119 subjects were found to be elevated, with noon and evening levels more than twice as high as during the non-pregnant state. Despite the hypercortisoli...

journal_title：Psychoneuroendocrinology

authors： de Weerth C,Buitelaar JK

更新日期：2005-10-01 00:00:00

abstract：:The neuroendocrine consequences of repeated exposure of the pregnant mother to relevant stressors have been studied in the offspring, but not in the mothers. As these stress effects might depend on the genetically determined stress susceptibility of the dams, here, we investigated the effects of daily exposure to psyc...

journal_title：Psychoneuroendocrinology

authors： Neumann ID,Krömer SA,Bosch OJ

更新日期：2005-09-01 00:00:00

abstract：:The diurnal rhythm of cortisol secretion in chronic disease can reflect the interactions between exogenous and endogenous factors. Exogenous glucocorticoid use may impact salivary cortisol measurements, but this has not been well-studied in ambulatory settings. In this report salivary cortisol levels were used to eval...

journal_title：Psychoneuroendocrinology

authors： Masharani U,Shiboski S,Eisner MD,Katz PP,Janson SL,Granger DA,Blanc PD

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The measurement of bioavailable testosterone (BT) or free testosterone (FT) levels is currently considered the gold standard for the diagnosis of androgen deficiency in elderly men. While the impact of age on circulating testosterone levels (total, bioavailable and free) has been strongly documented, the exi...

journal_title：Psychoneuroendocrinology

authors： Tancredi A,Reginster JY,Luyckx F,Legros JJ

更新日期：2005-08-01 00:00:00

abstract：:Psychosocial stress is a potent activator of the hypothalamus-pituitary-adrenal (HPA) axis. While the physiological mechanisms of HPA axis responses to stress as well as its short and long-term consequences have been extensively examined, less is known why someone elicits an acute neuroendocrine stress response, i.e. ...

journal_title：Psychoneuroendocrinology

authors： Gaab J,Rohleder N,Nater UM,Ehlert U

更新日期：2005-07-01 00:00:00

abstract：:Recently it has been reported that during insulin-induced hypoglycemia selective attention is directed to food stimuli suggesting an adaptive cognitive strategy to escape from this potentially dangerous metabolic state. Here, we tested this hypothesis using a short-term memory task. We also aimed to define a hypoglyce...

journal_title：Psychoneuroendocrinology

authors： Schultes B,Peters A,Kern W,Gais S,Oltmanns KM,Fehm HL,Born J

更新日期：2005-06-01 00:00:00

abstract：:The potential role of estrogen in protecting women from cognitive decline and reducing depressive symptoms is of great therapeutic interest. In a pilot randomised placebo controlled cross-over study, we aimed to determine the short-term effects of transdermal estradiol therapy on cognition and depressive symptoms in h...

journal_title：Psychoneuroendocrinology

authors： Schiff R,Bulpitt CJ,Wesnes KA,Rajkumar C

更新日期：2005-05-01 00:00:00

abstract：:This study investigated whether over-general retrieval of autobiographical memories in depression is related to increased basal cortisol levels. Forty-seven individuals with a current diagnosis of major depression were given the autobiographical memory test, in which they were asked to produce specific autobiographica...

journal_title：Psychoneuroendocrinology

authors： Barnhofer T,Kuehn EM,de Jong-Meyer R

更新日期：2005-05-01 00:00:00

abstract：:We measured affect in 334 healthy adults on each of 7 days over a 3-week period. On the last day, salivary cortisol was assessed 14 times yielding scores for total concentration, morning rise amplitude, and slope of the time function. Trait negative affect (NA) was associated with higher total cortisol concentrations ...

journal_title：Psychoneuroendocrinology

authors： Polk DE,Cohen S,Doyle WJ,Skoner DP,Kirschbaum C

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Previous research examining biological correlates of posttraumatic stress disorder (PTSD) in children has suggested that children with chronic PTSD have altered levels of catecholamines and cortisol compared to similarly traumatized children who do not meet diagnostic criteria. The present study extended the...

journal_title：Psychoneuroendocrinology

authors： Delahanty DL,Nugent NR,Christopher NC,Walsh M

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Hypopituitary patients with growth hormone deficiency (GHD) complain of reduced vitality, general fatigue, lack of concentration, irritability and reduced alertness during daytime. It is unclear whether these symptoms are primarily due to GH-deficiency and/or secondary to GHD related sleep impairments. Bi-di...

journal_title：Psychoneuroendocrinology

authors： Schneider HJ,Oertel H,Murck H,Pollmächer T,Stalla GK,Steiger A

更新日期：2005-01-01 00:00:00

abstract：:Females have a higher prevalence than men of neuropsychiatric disorders in which dopaminergic abnormalities play a prominent role, e.g. very late-onset schizophrenia and Parkinson's disease (PD). The biological basis of these sex differences is unknown but may include modulation of the dopaminergic system by sex hormo...

journal_title：Psychoneuroendocrinology

authors： Craig MC,Cutter WJ,Wickham H,van Amelsvoort TA,Rymer J,Whitehead M,Murphy DG

更新日期：2004-11-01 00:00:00

abstract：:Intravenous injections of CCK-B agonists, such as pentagastrin, produce symptoms of panic and potent activation of the human hypothalamic-pituitary-adrenal (HPA) axis. It is unclear whether these psychological and endocrine effects are mediated by similar or independent processes. Independence is supported by prior ev...

journal_title：Psychoneuroendocrinology

authors： Khan S,Liberzon I,Abelson JL

更新日期：2004-10-01 00:00:00

abstract：:There is a substantial amount of evidence indicating control over ethanol intake by steroid hormones, particularly adrenal glucocorticoids. Thus far, however, studies employing pharmacological methods have failed to find effects of glucocorticoid receptor blockade on voluntary ethanol consumption. Since length of etha...

journal_title：Psychoneuroendocrinology

authors： Koenig HN,Olive MF

更新日期：2004-09-01 00:00:00

abstract：:Allostatic load, the physiological accumulation of the effects of chronic stressors, has been associated with multiple adverse health outcomes. Flattened diurnal cortisol rhythmicity is one of the prototypes of allostatic load, and has been shown to predict shorter survival among women with metastatic breast cancer. T...

journal_title：Psychoneuroendocrinology

authors： Abercrombie HC,Giese-Davis J,Sephton S,Epel ES,Turner-Cobb JM,Spiegel D

更新日期：2004-09-01 00:00:00

abstract：:Ghrelin, the endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor and some GHSs exert different effects on sleep electroencephalogram (EEG) and sleep-related hormone secretion in humans. Similar to GH-releasing hormone (GHRH) ghrelin promotes slow-wave sleep in humans, whereas GH-releasing peptide-...

journal_title：Psychoneuroendocrinology

authors： Frieboes RM,Antonijevic IA,Held K,Murck H,Pollmächer T,Uhr M,Steiger A

更新日期：2004-08-01 00:00:00

abstract：:Animal research has demonstrated reductions in punishment sensitivity and enhanced reward dependency after testosterone administration. In humans, elevated levels of testosterone have been associated with violent and antisocial behavior. Interestingly, extreme forms of violent and antisocial behavior can be observed i...

journal_title：Psychoneuroendocrinology

authors： van Honk J,Schutter DJ,Hermans EJ,Putman P,Tuiten A,Koppeschaar H

更新日期：2004-08-01 00:00:00

abstract：:The effects of corticosteroids on memory performance have been the subject of some controversy. Whilst many studies have shown that high levels of corticosteroids can impair memory performance, others have shown they can facilitate it. One explanation for these discrepant effects arises from the differential activatio...

journal_title：Psychoneuroendocrinology

authors： Tytherleigh MY,Vedhara K,Lightman SL

更新日期：2004-07-01 00:00:00

abstract：:This study tested the hypothesis that prenatal androgen levels influence hand preferences and language lateralization, two manifestations of neural asymmetry. Participants were individuals with congenital adrenal hyperplasia (CAH, a genetic disorder that results in excess adrenal androgen production beginning prenatal...

journal_title：Psychoneuroendocrinology

authors： Mathews GA,Fane BA,Pasterski VL,Conway GS,Brook C,Hines M

更新日期：2004-07-01 00:00:00

abstract：:Successful mental aging may be defined as maintenance of youthful attitudes, cognitive and adaptational processes despite advanced age. Maintenance of homeostasis and efficient adaptational processes are of utmost importance. It is suggested that multiple hormonal systems and processes are involved in the multidimensi...

journal_title：Psychoneuroendocrinology

authors： Halbreich U

更新日期：2004-07-01 00:00:00

abstract：:In this single-blind study the effects of acute oral administration of the selective noradrenaline reuptake inhibitor reboxetine on the cortisol (COR), ACTH, growth hormone (GH) and prolactin (PRL) secretion were examined in 12 healthy male volunteers. In a randomized order, the subjects received placebo or reboxetine...

journal_title：Psychoneuroendocrinology

authors： Schüle C,Baghai T,Schmidbauer S,Bidlingmaier M,Strasburger CJ,Laakmann G

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Our laboratory has previously reported that testosterone (T) administration to older men significantly improves cognitive function. This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their r...

journal_title：Psychoneuroendocrinology

authors： Cherrier MM,Plymate S,Mohan S,Asthana S,Matsumoto AM,Bremner W,Peskind E,Raskind M,Latendresse S,Haley AP,Craft S

更新日期：2004-01-01 00:00:00

abstract：:Heightened cortisol levels due to stress or acute administration seem to enhance memory for emotional material, independently of emotional valence. An arousal-driven neurobiological mechanism involving the amygdala has been proposed. The relation between pre-task salivary measures of cortisol (by convention named 'bas...

journal_title：Psychoneuroendocrinology

authors： Van Honk J,Kessels RP,Putman P,Jager G,Koppeschaar HP,Postma A

更新日期：2003-10-01 00:00:00